Therapeutic hypothermia for neonates with hypoxic ischemic encephalopathy

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Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy.

BACKGROUND Hypothermia is protective against brain injury after asphyxiation in animal models. However, the safety and effectiveness of hypothermia in term infants with encephalopathy is uncertain. METHODS We conducted a randomized trial of hypothermia in infants with a gestational age of at least 36 weeks who were admitted to the hospital at or before six hours of age with either severe acid...

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Phase Changing Material for Therapeutic Hypothermia in Neonates with Hypoxic Ischemic Encephalopathy - A Multi-centric Study.

OBJECTIVE To assess the feasibility and safety of cooling asphyxiated neonates using phase changing material based device across different neonatal intensive care units in India. DESIGN Multi-centric uncontrolled clinical trial. SETTING 11 level 3 neonatal units in India from November 2014 to December 2015. PARTICIPANTS 103 newborn infants with perinatal asphyxia, satisfying pre-defined c...

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Hypothermia for newborns with hypoxic ischemic encephalopathy.

Hypoxic ischemic encephalopathy (HIE) remains a significant cause of mortality and long-term disability in late preterm and term infants. Mild therapeutic hypothermia to a rectal temperature of 34±0.5°C initiated as soon as possible within the first 6 h of life decreases mortality and severe long-term neurodevelopmental disabilities in infants with moderate HIE who are ≥36 weeks' gestational ag...

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Therapeutic hypothermia: treatment for hypoxic-ischemic encephalopathy in the NICU.

Baby M was born limp, blue, and without respiratory effort at 38 weeks gestation to a 38-year-old, gravida 5, para 1, woman. Delivery was vaginal after a rapid progression of labor leaving no opportunity for a cesarean section. No other complications were noted during labor but a large surge at delivery, later diagnosed as uterine rupture, initially raised concerns about placental abruption. Ap...

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Emerging Use of Therapeutic Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy

Objective: Several clinical trials evaluating the efficacy of hypothermia in neonates with encephalopathy have shown significant reduction in death and disability at 18-month follow-up. We sought to: 1) evaluate how the use of hypothermia for neonatal hypoxic ischemic encephalopathy (HIE) is changing in U.S. clinical practice, 2) determine which methods and devices for delivering hypothermia ar...

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ژورنال

عنوان ژورنال: Pediatrics & Neonatology

سال: 2017

ISSN: 1875-9572

DOI: 10.1016/j.pedneo.2016.11.001